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Enhanced penetration strategies for transdermal delivery
Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu
《化学科学与工程前沿(英文)》 2020年 第14卷 第3期 页码 378-388 doi: 10.1007/s11705-019-1913-1
关键词: transdermal delivery stratum corneum enhanced penetration therapeutics
微针递送系统用于皮肤疾病的局部增效治疗——应用、挑战和前景 Review
龚明宇, 陈杨燕, 胡婉姗, 陆超, 潘昕, 彭婷婷, 陈天祥, 吴传斌
《工程(英文)》 2023年 第30卷 第11期 页码 170-189 doi: 10.1016/j.eng.2023.05.009
微针能直接将治疗药物递送到皮肤病变部位,从而提高治疗效果和降低副作用,因而可用于皮肤疾病的局部治疗。微针可以递送不同种类的治疗药物(如小分子药物、大分子药物、纳米药物、活细胞、细菌和外泌体)来治疗各种皮肤疾病,包括浅表肿瘤、伤口、皮肤感染、炎症性皮肤病和异常皮肤外观。微针的治疗效率可以通过以下几种策略来提高:①整合不同治疗方法的优点来进行联合治疗;②对微针的结构进行仿生设计或者赋予微针内外源响应性释药性能来提高药物的经皮递送效率。一些研究提出将无药物微针发展为一种有前景的机械治疗方法,即通过微针的机械刺激产生机械转导信号来促进伤口愈合、疤痕消退和毛发再生。虽然微针具有诸多优点,但微针的实际应用还存在工业化生产和临床评价难等问题,进而制约微针的临床转化。本文总结了微针在皮肤疾病中的各种应用、新出现的挑战和发展前景,为微针的临床转化思路提供借鉴。
Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems
Ranvijay KUMAR, Kaushlendra SHARMA
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 116-122 doi: 10.1007/s11705-013-1310-0
关键词: psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation
Engineering platelet-mimicking drug delivery vehicles
Quanyin Hu, Hunter N. Bomba, Zhen Gu
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 624-632 doi: 10.1007/s11705-017-1614-6
关键词: drug delivery platelets nanomedicine bio-inspired biomimetic
Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 521-528 doi: 10.1007/s11705-017-1612-8
关键词: α-helical polypeptide plant gene delivery protoplast intact leaves transfection
Zhijian CHEN, Wei LI,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 1-1 doi: 10.1007/s11705-009-0306-2
Controlled drug delivery systems: the next 30 years
Yeonhee YUN,Byung Kook LEE,Kinam PARK
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 276-279 doi: 10.1007/s11705-014-1426-x
关键词: drug delivery history formulation barriers nanotechnology clinical product
Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy
《化学科学与工程前沿(英文)》 2023年 第17卷 第4期 页码 483-489 doi: 10.1007/s11705-022-2227-2
关键词: bioorthogonal reaction cancer therapy metabolic glycoengineering bioorthogonal catalytic patch
Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 473-480 doi: 10.1007/s11684-016-0479-
Aiming to control rising medical expenditures and help improve China’s healthcare systems, this study examined whether a cap-based medical insurance scheme with shared financial interest between the insurance and healthcare providers is effective in containing hospitals’ C-section medical expenditures. We used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital located in Wuxi, China (2004–2013), and used the Chow test to investigate the possibility of significant variation in mean medical expenditures for caesarean deliveries pre- and post-reform. We also used paired sample t-tests and linear regression models to compare the mean medical expenditures between insured and uninsured women undergoing caesarean delivery during the post-reform period. After the scheme’s implementation, medical expenditures for caesarean deliveries declined and the medical expenditures of women covered by the scheme were significantly lower than those of uninsured patients. These findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures. The cap-based medical insurance scheme with shared financial interest between insurance and healthcare providers would likely steer healthcare providers’ behaviors in a more cost-effective direction.
关键词: maternity insurance scheme financial incentive caesarean delivery medical expenditure China
Economic analysis of a hybrid solar-fuel cell power delivery system using tuned genetic algorithm
Trina SOM, Niladri CHAKRABORTY
《能源前沿(英文)》 2012年 第6卷 第1期 页码 12-20 doi: 10.1007/s11708-012-0172-3
关键词: distributed energy resources (DERs) microgrid tuned genetic algorithm (TGA)
Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review
Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 221-237 doi: 10.1007/s11705-020-1927-8
关键词: zeolitic imidazolate framework-8 (ZIF-8) synthesis methods applications drug delivery
Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,
《工程(英文)》 doi: 10.1016/j.eng.2023.05.024
关键词: Polysaccharides Chitosan Hydrogels Oral delivery Intestine-targeted
Barriers to advancing nanotechnology to better improve and translate nanomedicines
Yuwei WANG,David W. Grainger
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 265-275 doi: 10.1007/s11705-014-1442-x
关键词: nanotechnology nanomedicine drug delivery therapeutic target delivery
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao, Xiaoxuan Liu, Ling Peng
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 663-675 doi: 10.1007/s11705-017-1623-5
关键词: gene therapy RNAi therapeutics dendrimer nanovectors gene silencing
Significance and strategies in developing delivery systems for bio-macromolecular drugs
Huining HE, Qiuling LIANG, Meong Cheol SHIN, Kyuri LEE, Junbo GONG, Junxiao YE, Quan LIU, Jingkang WANG, Victor YANG
《化学科学与工程前沿(英文)》 2013年 第7卷 第4期 页码 496-507 doi: 10.1007/s11705-013-1362-1
关键词: delivery systems bio-macromolecular drugs cell penetrating peptides
标题 作者 时间 类型 操作
Enhanced penetration strategies for transdermal delivery
Qiaofei Pan, Yinglin Yu, Dong Chen, Genlong Jiao, Xiaowen Liu
期刊论文
Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems
Ranvijay KUMAR, Kaushlendra SHARMA
期刊论文
Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery
Zhijian CHEN, Wei LI,
期刊论文
Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,
null
期刊论文
Economic analysis of a hybrid solar-fuel cell power delivery system using tuned genetic algorithm
Trina SOM, Niladri CHAKRABORTY
期刊论文
Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review
Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang
期刊论文
A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics
Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,
期刊论文
Barriers to advancing nanotechnology to better improve and translate nanomedicines
Yuwei WANG,David W. Grainger
期刊论文
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao, Xiaoxuan Liu, Ling Peng
期刊论文